Endoxan-N 1 G Injection

Description

Endoxan-N 1 G Injection contains Cyclophosphamide, a powerful alkylating agent used in chemotherapy. It works by interfering with the DNA replication process in rapidly dividing cells, leading to cell death. This makes it highly effective in treating various types of cancers, including hematological malignancies and solid tumors.

Cyclophosphamide is also used in certain autoimmune and inflammatory conditions, such as lupus nephritis or severe vasculitis, under strict medical supervision, due to its immunosuppressive effects.

Endoxan-N 1 G is typically administered intravenously under close monitoring in a hospital or clinical setting because of its potency and potential for serious side effects.

---

Uses of Endoxan-N 1 G Injection

• Cancer therapy:

  • Breast cancer

  • Ovarian cancer

  • Lymphoma and leukemia

  • Multiple myeloma

• Autoimmune conditions (off-label use under supervision):

  • Systemic lupus erythematosus (SLE)

  • Severe vasculitis

• As part of combination chemotherapy regimens to enhance efficacy against resistant tumors

---

How It Works

• Cyclophosphamide is converted in the liver to active metabolites.

• These metabolites form cross-links in DNA, preventing the cancer cells from replicating and dividing.

• Rapidly dividing cells, such as cancer cells, are more susceptible, leading to cell death and tumor reduction.

• The drug also suppresses overactive immune cells in autoimmune conditions.

---

Dosage and Administration

• Administered intravenously by a qualified healthcare professional.

• Dose varies depending on:

  • Type and stage of cancer

  • Patient’s body surface area

  • Combination with other chemotherapy agents

• Usually given in cycles, with rest periods to allow the body to recover.

• Close monitoring of blood counts, liver, and kidney function is essential.

---

Side Effects

Common side effects:

• Nausea and vomiting

• Hair loss (alopecia)

• Fatigue

• Decreased blood cell counts (risk of infection, anemia, or bleeding)

Serious side effects:

• Severe immunosuppression leading to infections

• Bladder toxicity (hemorrhagic cystitis)

• Liver or kidney dysfunction

• Allergic reactions (rash, swelling, difficulty breathing)

• Risk of secondary cancers with long-term use

Patients are advised to report any unusual bleeding, fever, or persistent fatigue immediately.

---

Precautions

• Use only under strict medical supervision.

• Regular monitoring of blood counts, kidney, and liver function is mandatory.

• Maintain adequate hydration to reduce risk of bladder toxicity.

• Avoid pregnancy; use effective contraception during and after treatment.

• Patients should avoid exposure to infections due to immunosuppression.

---

Drug Interactions

• Other chemotherapy agents – may increase toxicity

• Vaccines – live vaccines should be avoided

• Immunosuppressants – additive effects on immune suppression

• Drugs affecting liver enzymes – may alter metabolism of Cyclophosphamide

All concomitant medications should be discussed with the oncologist.

---

Storage Instructions

• Store below 25°C, protected from light.

• Keep in original packaging until use.

• Use immediately after reconstitution or as directed by the healthcare professional.

---

Key Benefits of Endoxan-N 1 G Injection

• Effective anti-cancer therapy for a variety of malignancies

• Can be combined with other chemotherapy agents for enhanced effect

• Immunosuppressive properties helpful in autoimmune disorders

• Administered under controlled conditions to maximize efficacy and minimize toxicity