Duopil-HS 2/850 Tablet PR

Description

Duopil-HS 2/850 Tablet PR is a combination oral anti-diabetic medicine used for managing Type 2 Diabetes Mellitus (T2DM) in adults. It contains Glimepiride (2 mg), a sulfonylurea that increases insulin secretion from the pancreas, and Metformin (850 mg, Prolonged Release), a biguanide that reduces liver glucose production, delays intestinal glucose absorption, and improves insulin sensitivity.

The HS (High Strength) variant provides an intermediate balance between Duopil 2/500 and Duopil 2 Forte (2/1000), making it suitable for patients who require stronger glycemic control than 500 mg Metformin but cannot tolerate the higher 1000 mg dose.

The PR (Prolonged Release) formulation of Metformin ensures steady glucose control throughout the day with reduced gastrointestinal side effects compared to immediate-release tablets.

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Uses / Indications

• Type 2 Diabetes Mellitus (T2DM)

• Patients inadequately controlled by diet, exercise, or monotherapy

• Helps reduce both fasting and postprandial blood glucose

• Prevents diabetes-related complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease

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How It Works (Mechanism of Action)

• Glimepiride (2 mg): Stimulates pancreatic beta cells to release more insulin → lowers blood sugar.

• Metformin (850 mg PR):

  • Decreases hepatic glucose production

  • Slows down absorption of glucose from the intestine

  • Increases insulin sensitivity in peripheral tissues

• Combined Effect: Dual action ensures better glycemic control throughout the day.

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Dosage & Administration

• Usually prescribed once daily with meals, or as directed by the physician.

• Swallow whole with water; do not crush or chew (due to prolonged-release action).

• Dosage may be adjusted depending on blood glucose monitoring and tolerance.

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Side Effects

Common:

• Hypoglycemia (sweating, dizziness, shakiness, hunger, palpitations)

• Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal discomfort)

• Headache, weakness, metallic taste

Serious (rare):

• Lactic acidosis (rare but serious; signs include muscle pain, extreme fatigue, difficulty breathing, irregular heartbeat)

• Severe hypoglycemia if meals are skipped or dosage is too high

• Allergic reactions (skin rash, itching, swelling, difficulty in breathing)

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Precautions & Warnings

• Not indicated for Type 1 Diabetes or diabetic ketoacidosis.

• Avoid alcohol to reduce risk of lactic acidosis and severe hypoglycemia.

• Caution in patients with kidney disease, liver impairment, heart failure, or adrenal/pituitary dysfunction.

• Should be paused before surgery or diagnostic tests with iodinated contrast dye.

• Use only under medical supervision during pregnancy or breastfeeding.

• Must be taken alongside a proper diet plan and regular exercise.

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Summary

Duopil-HS 2/850 Tablet PR combines Glimepiride (2 mg) and Metformin (850 mg PR) for effective control of Type 2 Diabetes. It helps by both stimulating insulin release and improving insulin efficiency while reducing glucose production. This HS variant is ideal for patients needing stronger control than 500 mg Metformin but unable to tolerate the 1000 mg dose. Regular use, combined with lifestyle measures, helps prevent long-term diabetes complications and promotes better metabolic health.