Description

Glycigon-M Tablet is a combination oral antidiabetic medicine that contains Gliclazide (80 mg) and Metformin (500 mg). It is used in the management of type 2 diabetes mellitus (T2DM) when blood sugar cannot be controlled by lifestyle changes or a single medicine alone. The dual action of Gliclazide and Metformin helps achieve better blood sugar control and reduces the risk of long-term diabetes complications such as heart disease, nerve problems, kidney damage, and vision issues.

Uses / Indications

Management of type 2 diabetes mellitus
Improves overall glycemic control when monotherapy (single drug) is inadequate
Helps lower the risk of macrovascular and microvascular complications of diabetes

How It Works (Mechanism of Action)

Gliclazide (80 mg): A sulfonylurea that stimulates the pancreas to release more insulin, thereby lowering blood glucose levels.
Metformin (500 mg): A biguanide that reduces glucose production in the liver, decreases intestinal absorption of sugar, and improves insulin sensitivity in muscles.
Together, they provide synergistic control of blood sugar by acting on different mechanisms.

Dosage & Administration

Usually taken once or twice daily with meals, as prescribed.
The dose depends on the patient’s blood sugar levels and response to therapy.
Regular monitoring of blood glucose and HbA1c is essential.
Do not skip meals after taking the tablet, as it increases the risk of hypoglycemia.

Side Effects

Common:

Hypoglycemia (sweating, dizziness, shakiness, hunger, palpitations)
Nausea, vomiting, stomach upset, diarrhea
Headache, weakness
Weight gain (due to Gliclazide)

Less common:

Metallic taste in mouth
Vitamin B12 deficiency (with long-term Metformin use)
Skin rash or itching

Serious (rare):

Lactic acidosis (very rare but life-threatening side effect of Metformin; symptoms: muscle pain, fatigue, difficulty breathing)
Severe allergic reaction
Liver or kidney dysfunction

Precautions & Warnings

Not suitable for type 1 diabetes or diabetic ketoacidosis.
Use with caution in patients with kidney, liver, or heart problems.
Avoid alcohol as it increases the risk of hypoglycemia and lactic acidosis.
Pregnant or breastfeeding women should use it only if prescribed by a doctor.
Regular monitoring of blood sugar is essential to avoid fluctuations.

Summary

Glycigon-M Tablet (Gliclazide 80 mg + Metformin 500 mg) is an effective combination antidiabetic medicine used in the treatment of type 2 diabetes mellitus. It helps regulate blood sugar by increasing insulin release and reducing glucose production, but requires careful monitoring to prevent hypoglycemia and lactic acidosis.

Glycigon-M Tablet