Duopil 1 Forte Tablet PR

Description

Duopil 1 Forte Tablet PR is an oral anti-diabetic medicine used in the management of Type 2 Diabetes Mellitus. It combines Glimepiride, a sulfonylurea that increases insulin secretion from the pancreas, and Metformin, a biguanide that improves insulin sensitivity and reduces glucose production in the liver. The PR (Prolonged Release) formulation ensures gradual release of the drug, providing sustained control of blood sugar levels throughout the day.

This dual therapy is recommended when blood sugar cannot be controlled with diet, exercise, and single-drug therapy. By working through complementary mechanisms, Duopil 1 Forte Tablet PR helps lower both fasting and post-meal blood glucose levels, reduces the risk of diabetes-related complications, and improves overall metabolic control.

Uses / Indications

• Type 2 Diabetes Mellitus (T2DM)

• Inadequate control of blood sugar with metformin or glimepiride alone

• Helps reduce the risk of long-term complications of diabetes such as kidney damage, nerve problems, and heart disease

How It Works (Mechanism of Action)

• Glimepiride (1 mg): Belongs to sulfonylureas; stimulates the pancreas to release more insulin, thereby lowering blood sugar.

• Metformin (1000 mg PR): Reduces glucose production in the liver, decreases intestinal absorption of sugar, and improves the body’s response to insulin.

• Combined Effect: Provides effective blood sugar control throughout the day with lower chances of fluctuations.

Dosage & Administration

• Usual dose: One tablet once daily, or as directed by the physician.

• Should be taken with meals to reduce stomach upset and risk of hypoglycemia.

• Swallow whole; do not crush or chew (since it is a prolonged-release tablet).

• Dosage may be adjusted depending on blood sugar response and tolerance.

Side Effects

Common side effects:

• Hypoglycemia (low blood sugar: sweating, dizziness, tremors, hunger, palpitations)

• Nausea, vomiting, diarrhea

• Stomach upset or metallic taste

• Headache or weakness

Rare but serious side effects:

• Lactic acidosis (serious but rare; symptoms include rapid breathing, severe weakness, muscle pain, irregular heartbeat)

• Severe hypoglycemia if meals are skipped or overdosed

• Allergic reactions like rash, itching, swelling

Precautions & Warnings

• Avoid alcohol while taking this medicine (increases risk of lactic acidosis and low blood sugar).

• Caution in patients with kidney or liver disease, heart problems, or adrenal/pituitary disorders.

• Not recommended during pregnancy or breastfeeding unless prescribed by a doctor.

• Inform your doctor if you are undergoing surgery or radiological tests with contrast dye, as metformin may need to be stopped temporarily.

• Maintain a proper diet and exercise regimen along with the medication.

Summary

Duopil 1 Forte Tablet PR is a combination anti-diabetic medicine containing Glimepiride 1 mg and Metformin 1000 mg (Prolonged Release). It effectively controls blood sugar levels in patients with type 2 diabetes by enhancing insulin secretion and improving insulin sensitivity. Regular use, along with lifestyle modifications, helps prevent complications of diabetes and improves quality of life.