Gifaxin 400 Tablet

Description

Gifaxin 400 Tablet contains Rifaximin (400 mg), a non-absorbable, broad-spectrum antibiotic. It acts primarily within the intestine and is not significantly absorbed into the bloodstream, which makes it safer compared to systemic antibiotics. It is prescribed for traveler’s diarrhea, irritable bowel syndrome with diarrhea (IBS-D), hepatic encephalopathy, and certain bacterial intestinal infections.

---

Uses / Indications

• Traveler’s diarrhea (caused by non-invasive E. coli)

• Irritable Bowel Syndrome with Diarrhea (IBS-D) – reduces bloating and stool frequency

• Hepatic encephalopathy – lowers the risk of recurrence by reducing ammonia-producing bacteria

• Small intestinal bacterial overgrowth (SIBO)

• Intestinal infections caused by susceptible bacteria

---

How It Works (Mechanism of Action)

• Rifaximin (400 mg): Blocks bacterial RNA synthesis, preventing growth and multiplication.

• Acts locally in the gastrointestinal tract, with minimal absorption → fewer systemic side effects.

• Helps restore gut balance by targeting harmful bacteria while sparing some beneficial flora.

---

Dosage & Administration

• Typical adult dose: 400 mg 2–3 times daily (depends on condition).

• Taken orally with or without food.

• Treatment duration varies:

  • Traveler’s diarrhea – usually 3 days

  • IBS-D – may be prescribed for 10–14 days

  • Hepatic encephalopathy – often long-term therapy as per doctor’s advice

• Always complete the full prescribed course.

(Dosage should always be confirmed by a doctor depending on the condition and patient profile.)

---

Side Effects

Common:

• Nausea, abdominal discomfort

• Flatulence, bloating, constipation or diarrhea

• Headache, dizziness

• Fatigue

Less common:

• Rash, itching

• Muscle pain or joint pain

Serious (rare):

• Severe diarrhea (possible Clostridium difficile infection)

• Allergic reactions (swelling of face/lips, difficulty in breathing)

• Liver-related side effects with prolonged use

---

Precautions & Warnings

• Not effective against systemic infections or diarrhea with blood/fever.

• Use with caution in severe liver impairment.

• Long-term use may lead to antibiotic resistance.

• Safety in pregnancy and breastfeeding not well established – use only if prescribed.

• Inform your doctor about any other medicines (e.g., cyclosporine, anticoagulants).

---

Summary

Gifaxin 400 Tablet (Rifaximin 400 mg) is a gut-specific antibiotic mainly prescribed for IBS-D, hepatic encephalopathy, traveler’s diarrhea, and intestinal bacterial overgrowth. It is effective and generally safe with mild digestive or neurological side effects, but must be taken under strict medical supervision to avoid resistance and complications.