Glimiprex MF Forte 1 Tablet PR

Description

Glimiprex MF Forte 1 Tablet PR is a combination antidiabetic medicine that contains Glimepiride (1 mg) and Metformin (1000 mg) in a prolonged-release (PR) formulation. It is prescribed for the management of type 2 diabetes mellitus (T2DM) when diet, exercise, and single-drug therapy are not sufficient to control blood sugar levels. The dual mechanism helps in improving insulin response and lowering glucose production in the liver, providing better long-term glycemic control.

Uses / Indications

• Management of type 2 diabetes mellitus

• Helps control blood glucose levels in patients not adequately managed with Metformin or Glimepiride alone

• Reduces risk of diabetes-related complications such as kidney damage, nerve problems, eye damage, and heart disease

How It Works (Mechanism of Action)

• Glimepiride (1 mg): A sulfonylurea that stimulates the pancreas to release more insulin.

• Metformin (1000 mg): A biguanide that reduces glucose production in the liver, decreases intestinal absorption of glucose, and improves the body’s sensitivity to insulin.

• The prolonged-release (PR) form ensures gradual release, maintaining stable blood sugar control with fewer gastrointestinal side effects.

Dosage & Administration

• Usually taken once daily with food to reduce stomach upset.

• The exact dose and timing depend on blood sugar levels, response, and doctor’s advice.

• Regular monitoring of blood glucose and HbA1c is recommended.

• Do not skip or double doses; consistency is key in diabetes management.

Side Effects

Common:

• Nausea, vomiting, diarrhea

• Abdominal discomfort, bloating

• Headache, dizziness

• Hypoglycemia (low blood sugar) – sweating, tremors, hunger, palpitations

Less common but possible:

• Weight gain (due to Glimepiride)

• Vitamin B12 deficiency (with long-term Metformin use)

• Metallic taste in mouth

Serious (rare):

• Lactic acidosis (very rare but serious, linked to Metformin; symptoms include muscle pain, tiredness, difficulty breathing)

• Severe allergic reaction

• Liver or kidney dysfunction

Precautions & Warnings

• Not recommended in type 1 diabetes or diabetic ketoacidosis.

• Use with caution in patients with kidney, liver, or heart disease.

• Alcohol intake should be limited, as it increases the risk of hypoglycemia and lactic acidosis.

• Pregnant or breastfeeding women should consult their doctor before use.

• Regular blood sugar monitoring is essential to avoid both hyperglycemia and hypoglycemia.

Summary

Glimiprex MF Forte 1 Tablet PR combines Glimepiride (1 mg) and Metformin (1000 mg) to provide dual action in controlling type 2 diabetes mellitus. It helps lower blood sugar effectively, reducing the risk of diabetes complications, but requires careful monitoring to prevent hypoglycemia and gastrointestinal side effects.