Description
Glycigon-M SR Tablet is a combination oral antidiabetic medicine that contains Gliclazide (80 mg) and Metformin (500 mg) in a sustained-release (SR) formulation. It is prescribed for the treatment of type 2 diabetes mellitus (T2DM) when blood sugar levels cannot be managed effectively with diet, exercise, or single-drug therapy. The sustained-release form ensures gradual release of the medicine, helping maintain more stable blood sugar levels with fewer gastrointestinal side effects compared to immediate-release formulations.
Uses / Indications
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Treatment and management of type 2 diabetes mellitus
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Helps control both fasting and post-meal blood glucose levels
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Reduces the risk of long-term complications like heart disease, kidney damage, neuropathy, and retinopathy
How It Works (Mechanism of Action)
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Gliclazide (80 mg): A sulfonylurea that increases insulin secretion from pancreatic beta cells.
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Metformin (500 mg): A biguanide that reduces glucose production in the liver, decreases absorption of glucose in the intestines, and improves insulin sensitivity in the body.
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Sustained-release (SR): Provides slower and steady release, improving tolerability and maintaining stable blood sugar control.
Dosage & Administration
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Usually taken once or twice daily with meals, as prescribed by the doctor.
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Dose depends on blood sugar levels, HbA1c, and patient response.
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Must be taken consistently, at the same time each day.
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Do not skip meals after taking this medicine, as it may lead to hypoglycemia.
Side Effects
Common:
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Hypoglycemia (sweating, dizziness, hunger, tremors, palpitations)
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Nausea, vomiting, diarrhea, abdominal discomfort
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Headache, weakness
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Weight gain (due to Gliclazide)
Less common:
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Metallic taste in mouth
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Vitamin B12 deficiency with long-term Metformin use
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Mild skin rash
Serious (rare):
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Lactic acidosis (a rare but serious Metformin side effect; symptoms include severe weakness, muscle pain, trouble breathing)
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Severe allergic reaction
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Liver or kidney dysfunction
Precautions & Warnings
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Not recommended for type 1 diabetes or diabetic ketoacidosis.
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Use cautiously in patients with kidney, liver, or heart problems.
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Avoid alcohol intake to prevent hypoglycemia and lactic acidosis.
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Not recommended in pregnancy or breastfeeding unless prescribed by a doctor.
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Regular monitoring of blood glucose and HbA1c is necessary.
Summary
Glycigon-M SR Tablet (Gliclazide 80 mg + Metformin 500 mg SR) is an effective dual-action antidiabetic combination that helps control blood sugar in type 2 diabetes mellitus. The sustained-release form provides steady glucose control with better tolerability, but patients must take it with meals and monitor for hypoglycemia or lactic acidosis.
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