Megapen Capsule

Description

Megapen Capsule is a broad-spectrum oral antibiotic used to treat bacterial infections. It combines:

• Ampicillin (250mg): A penicillin-class antibiotic effective against a wide range of Gram-positive and some Gram-negative bacteria by inhibiting bacterial cell wall synthesis.

• Cloxacillin (250mg): A penicillinase-resistant antibiotic that is particularly effective against penicillin-resistant Staphylococcus aureus.

This combination ensures enhanced antibacterial coverage for mixed infections and resistant strains.

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Uses / Indications

• Respiratory tract infections (pneumonia, bronchitis, sinusitis)

• Ear, nose, and throat infections (tonsillitis, pharyngitis, otitis media)

• Skin and soft tissue infections (abscesses, cellulitis)

• Urinary tract infections (UTIs)

• Bone and joint infections

• Mixed bacterial infections requiring broad coverage

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How It Works

• Ampicillin disrupts bacterial cell wall synthesis, leading to bacterial lysis.

• Cloxacillin resists degradation by penicillinase enzymes, ensuring effectiveness against resistant bacteria.

• Together, they provide broad-spectrum coverage, targeting both susceptible and penicillinase-producing bacteria.

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Dosage & Administration

• Usually taken 1–2 capsules every 6–8 hours, or as prescribed by a doctor.

• Swallow capsules whole with water, preferably before meals.

• Complete the full course even if symptoms improve to prevent bacterial resistance.

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Side Effects

Common:

• Nausea or mild stomach upset

• Diarrhea or loose stools

• Mild skin rash

Less Common / Rare:

• Allergic reactions (itching, hives, swelling)

• Dizziness or headache

Serious (rare):

• Severe allergic reactions (anaphylaxis)

• Liver dysfunction (elevated liver enzymes, jaundice)

• Clostridium difficile-associated diarrhea

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Precautions & Warnings

• Avoid in patients with penicillin allergy.

• Use cautiously in renal or hepatic impairment.

• Complete the prescribed course to prevent resistant infections.

• Pregnant or breastfeeding women should use only if prescribed.

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Summary

Megapen Capsule (Ampicillin 250mg + Cloxacillin 250mg) is a broad-spectrum antibiotic for treating respiratory, ENT, skin, urinary, and mixed bacterial infections. Its combination of ampicillin and cloxacillin ensures enhanced antibacterial coverage, and it should be taken under medical supervision with adherence to the full course for optimal results.