Description
Okamet GMP 1 Tablet is a triple combination oral antidiabetic medicine manufactured by Cipla Ltd. It contains Glimepiride 1mg, Metformin Hydrochloride 500mg (Sustained Release), and Pioglitazone 15mg. This medicine is prescribed for the management of Type 2 Diabetes Mellitus when diet, exercise, and dual therapy do not provide adequate control.
How Okamet GMP 1 Works
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Glimepiride (1mg): A sulfonylurea that increases insulin secretion from the pancreas, lowering blood glucose after meals.
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Metformin SR (500mg): A biguanide that reduces glucose production in the liver, delays sugar absorption from the intestines, and enhances insulin sensitivity in the body.
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Pioglitazone (15mg): A thiazolidinedione that improves the body’s response to insulin, allowing better glucose utilization in muscles and fat tissues.
Together, these three medicines act through different mechanisms to provide powerful and comprehensive blood sugar control, targeting both fasting and postprandial (after meal) glucose levels.
Uses of Okamet GMP 1 Tablet
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Management of Type 2 Diabetes Mellitus in patients not adequately controlled with diet, exercise, and dual therapy.
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Helps in controlling fasting and post-meal sugar levels.
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Prevents or delays complications of uncontrolled diabetes such as:
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Diabetic neuropathy (nerve damage causing tingling, numbness, burning sensation)
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Diabetic nephropathy (kidney damage leading to protein in urine)
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Diabetic retinopathy (eye damage and vision loss)
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Cardiovascular diseases (heart attack, stroke)
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Provides strong control for patients requiring triple-drug therapy.
Dosage & Administration
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Usually taken once daily with a main meal, preferably breakfast.
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Swallow the tablet whole with water; do not crush or chew.
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Dose is individualized based on blood glucose levels and doctor’s advice.
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Regular monitoring of blood sugar, HbA1c, kidney and liver function tests is necessary.
Precautions
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Not suitable for Type 1 Diabetes or diabetic ketoacidosis.
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Use cautiously in patients with heart failure, liver disease, or kidney problems (due to Pioglitazone and Metformin).
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Avoid alcohol as it increases the risk of lactic acidosis and severe hypoglycemia.
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May cause fluid retention or weight gain (due to Pioglitazone).
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Should be used in pregnancy or breastfeeding only under strict medical supervision.
Possible Side Effects
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Hypoglycemia (sweating, dizziness, hunger, weakness)
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Stomach upset, nausea, diarrhea (from Metformin)
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Weight gain, fluid retention, or ankle swelling (from Pioglitazone)
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Headache or dizziness
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Rare but serious: Lactic acidosis, liver dysfunction, or worsening of heart failure
Overall Benefit
Okamet GMP 1 Tablet offers a triple mechanism of action by combining Glimepiride, Metformin SR, and Pioglitazone, making it highly effective in controlling Type 2 Diabetes when dual therapy is insufficient. It helps maintain stable sugar levels throughout the day, reduces the risk of long-term complications, and supports improved overall health and quality of life.
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