PRULOFORD-1

Description

PRULOFORD-1 contains prucalopride, a selective serotonin 5-HT4 receptor agonist prescribed for the treatment of chronic idiopathic constipation (CIC)—long-term constipation with no identifiable cause—in adults. It is supplied as a film-coated tablet in a strip for oral use.

Clinical Uses

• Chronic idiopathic constipation in adults, especially when other laxatives have failed or provided inadequate relief.

• Can alleviate symptoms such as infrequent bowel movements, difficult evacuation, and persistent incomplete emptying.

• Occasionally used in irritable bowel syndrome with predominant constipation (IBS-C).

Mechanism of Action

Prucalopride acts as a selective and high-activity serotonin 5-HT4 receptor agonist in the colon, stimulating the release of acetylcholine and increasing bowel motility. This helps restore the normal frequency and efficiency of bowel movements.

Dosage & Administration

• The usual dose is 1 mg once daily, as prescribed by the physician.

• May be taken with or without food, at any time of day.

• Do not use in children under 18 years; not recommended during pregnancy/breastfeeding unless advised by the doctor.

Common Side Effects

• Headache, stomach pain, nausea, diarrhea, dizziness, fatigue, decreased appetite, or abnormal gastrointestinal sounds.

• Most side effects are mild and resolve as the body adjusts; inform the doctor if they persist or worsen.

Precautions & Safety Advice

• Not suitable for patients with severe kidney, liver, or heart problems.

• Tell your doctor about all medications and conditions before starting; inform if constipation hasn’t improved after 4 weeks of therapy.

• May cause mild dizziness—use caution while driving or operating machinery.

PRULOFORD-1 is a prescription prokinetic tablet for safe, targeted management of chronic, treatment-resistant constipation.