Description
Rosugard 40 Tablet is a high-strength cholesterol-lowering medicine manufactured by Cipla Ltd. It contains Rosuvastatin (40mg), one of the most potent statins used in the treatment of severe hyperlipidemia (very high cholesterol levels) and in patients at high risk of cardiovascular events. This dose is usually prescribed when lower doses (5mg, 10mg, or 20mg) fail to provide adequate cholesterol control.
How It Works
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Rosuvastatin (40mg): Inhibits the enzyme HMG-CoA reductase, the key enzyme responsible for cholesterol production in the liver.
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Reduces LDL cholesterol (bad cholesterol) and triglycerides, while increasing HDL cholesterol (good cholesterol).
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Helps prevent plaque build-up in arteries, reducing the chances of atherosclerosis, heart attack, and stroke.
Medical Uses
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Treatment of severe hypercholesterolemia
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Management of mixed dyslipidemia (high LDL + high triglycerides + low HDL)
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Prevention of major cardiovascular events in high-risk patients (with diabetes, hypertension, smoking, obesity, or family history of heart disease)
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Used in patients who did not respond adequately to lower rosuvastatin doses
Benefits
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Provides powerful cholesterol-lowering effects in severe cases
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Reduces the risk of heart attack, stroke, and revascularization procedures
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Improves arterial health by reducing cholesterol deposition
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Beneficial for patients with genetic lipid disorders (like familial hypercholesterolemia)
Possible Side Effects
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Headache, nausea, abdominal pain, constipation
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Muscle pain, weakness, joint pain
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Increased liver enzymes (monitoring required)
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Rare but serious: Rhabdomyolysis (severe muscle damage), kidney problems
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May increase blood sugar levels in some patients
Warnings & Precautions
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Not first-line therapy; used only when lower doses are insufficient
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Regular liver and kidney function monitoring is necessary
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Avoid in pregnancy and breastfeeding
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Use cautiously in patients with liver disease, kidney impairment, thyroid issues, or heavy alcohol use
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Should be taken with a low-fat diet, regular exercise, and lifestyle modifications
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Avoid grapefruit juice as it can raise rosuvastatin levels in the body
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