Syncapone 150 Tablet

Description

Uses:
Syncapone 150 Tablet is a combination formulation indicated for the treatment of Parkinson’s disease and Parkinson’s-like symptoms such as tremors, stiffness, slowness of movement, and loss of coordination. The medicine combines three pharmacological agents:

• Levodopa: A dopamine precursor that crosses the blood–brain barrier and is converted into dopamine, compensating for dopamine deficiency in the brain.

• Carbidopa: A peripheral decarboxylase inhibitor that prevents the breakdown of Levodopa before it reaches the central nervous system, enhancing its efficacy and reducing peripheral side effects such as nausea.

• Entacapone: A catechol-O-methyltransferase (COMT) inhibitor that prolongs the duration of Levodopa’s effect by inhibiting its peripheral metabolism.
  Together, these agents provide improved symptom control and extended “on-time” in Parkinson’s disease management.

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How to Use:
Syncapone 150 Tablet should be taken orally, as prescribed by a neurologist or physician experienced in managing Parkinson’s disease. The tablet is to be swallowed whole with water and may be taken with or without food. Dosing intervals and frequency are individualized based on disease severity, previous Levodopa exposure, and patient response. Patients are advised not to discontinue therapy abruptly without medical consultation, as this may result in a rapid return or worsening of Parkinsonian symptoms.

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Precautions:

• Patients with hepatic impairment, cardiovascular disorders, or psychiatric conditions require dose adjustments and monitoring.

• Orthostatic hypotension may occur; patients should rise slowly from sitting or lying positions.

• Concurrent use of non-selective monoamine oxidase inhibitors (MAOIs) is contraindicated.

• Periodic monitoring of liver function, hematological parameters, and renal function is recommended during prolonged therapy.

• The medicine may cause somnolence; patients should avoid driving or operating heavy machinery until they understand how the medication affects them.

• Pregnant or lactating women should use this medication only if potential benefits justify potential risks.

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Dosage:
The dosage is determined by the prescribing physician based on prior dopaminergic therapy and clinical response. Typically, one tablet is administered several times daily, maintaining consistent dosing intervals. If a dose is missed, it should be taken promptly unless it is near the next scheduled dose. Doubling doses is contraindicated.

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Side Effects:
Reported adverse effects include:

• Nausea, vomiting, and abdominal discomfort

• Dizziness and orthostatic hypotension

• Fatigue and somnolence

• Dyskinesia or involuntary movements

• Hallucinations or confusion in some patients

• Diarrhea and change in urine coloration (dark or reddish-brown, non-pathological)

Serious adverse reactions such as severe dyskinesia, hallucinations, or cardiac irregularities require immediate medical evaluation.