Nubeta SM Tablet

Description

Nubeta SM Tablet is a prescription antihypertensive medicine that combines Nebivolol (5 mg), a selective beta-1 adrenergic blocker, and S-Amlodipine (2.5 mg), a calcium channel blocker (CCB). This fixed-dose combination by Abbott is specially designed for patients with hypertension (high blood pressure) who require more than one medicine to achieve adequate blood pressure control. By acting through two complementary mechanisms, Nubeta SM effectively lowers blood pressure, improves vascular health, and reduces the risk of heart attack, stroke, and other cardiovascular complications.

---

Therapeutic Uses:

• Hypertension (High Blood Pressure): Lowers elevated blood pressure and reduces long-term cardiovascular risk.

• Angina (chest pain due to reduced blood flow to the heart): Helps improve oxygen supply to the heart muscle.

• Prevention of cardiovascular complications: Lowers the risk of stroke, heart attack, and heart failure in hypertensive patients.

---

Mechanism of Action:

• Nebivolol (5 mg): A highly selective beta-1 blocker that reduces heart rate, myocardial oxygen demand, and cardiac output. Additionally, it enhances nitric oxide release, leading to vasodilation and improved blood vessel function.

• S-Amlodipine (2.5 mg): An active enantiomer of amlodipine that blocks calcium entry into vascular smooth muscle cells, causing arterial relaxation and vasodilation, thereby lowering blood pressure and reducing angina symptoms.

Together, these actions provide dual antihypertensive benefits by reducing both cardiac workload and vascular resistance.

---

Dosage & Administration:

• Take Nubeta SM Tablet once daily, exactly as prescribed by your doctor.

• Can be taken with or without food.

• Swallow whole with a glass of water.

• Do not discontinue the medicine suddenly without medical advice.

---

Side Effects:
Common:

• Headache, dizziness, or fatigue

• Flushing or swelling of ankles/feet (pedal edema)

• Slow heart rate (bradycardia)

• Gastrointestinal upset

Rare but serious:

• Severe hypotension

• Worsening heart failure symptoms

• Allergic reactions (rash, itching, swelling)

---

Precautions & Warnings:

• Use under medical supervision only.

• Not suitable for patients with:

  • Severe bradycardia or heart block

  • Acute heart failure

  • Severe liver impairment

• Caution in patients with kidney problems, asthma, or diabetes.

• May mask symptoms of low blood sugar in diabetics.

• Not recommended in pregnancy or breastfeeding unless advised by a doctor.

---

Drug Interactions:

• Other antihypertensives (risk of excessive BP lowering)

• Antiarrhythmic agents (risk of bradycardia)

• Calcium supplements or other CCBs

• Alcohol (may increase drowsiness and BP-lowering effect)

---

Storage:

• Store in a cool, dry place below 25°C.

• Protect from direct sunlight and moisture.

• Keep away from children.

---

Key Benefits:

• Dual therapy in a single tablet for convenient blood pressure management

• Provides better control for patients uncontrolled on single-drug therapy

• Reduces risk of stroke, heart attack, and other heart-related complications

• Improves patient adherence with once-daily dosing

• Trusted quality from Abbott

---

Conclusion:
Nubeta SM Tablet (Nebivolol 5 mg + S-Amlodipine 2.5 mg) is a highly effective dual-action antihypertensive that combines the heart-protective effect of a beta-blocker with the vasodilatory benefits of a calcium channel blocker. It ensures comprehensive blood pressure control, improved vascular function, and reduced cardiovascular risks, making it a valuable treatment option for patients with persistent hypertension.