Divalpro XR 250 Tablet

Description

Divalpro XR 250 Tablet is a extended-release (XR) formulation of Divalproex Sodium (250mg). It is used to manage epilepsy, bipolar disorder, and migraine prophylaxis. The extended-release formulation allows slow and sustained release of the active ingredient, providing longer-lasting therapeutic effects and reducing the frequency of dosing compared to regular tablets.

This formulation is particularly helpful in maintaining stable blood levels of the medication, which helps in preventing seizures, controlling mood swings, and reducing migraine frequency.

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Uses of Divalpro XR 250 Tablet

• Epilepsy: Management of generalized, partial, and absence seizures

• Bipolar disorder: Stabilizes mood and prevents mania

• Migraine prophylaxis: Reduces frequency and severity of migraine attacks

• Maintenance therapy for neurological and psychiatric conditions requiring steady drug levels

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How It Works

Divalproex acts by:

• Increasing GABA (gamma-aminobutyric acid) levels in the brain, an inhibitory neurotransmitter that reduces nerve excitability

• Stabilizing neuronal membranes, preventing excessive firing of nerve signals

• Maintaining balanced brain chemistry, aiding mood stabilization and seizure control

The extended-release mechanism ensures gradual absorption, minimizing peaks and troughs in drug concentration and improving tolerability.

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Dosage and Administration

• Taken orally, once or twice daily, depending on the doctor’s prescription.

• Swallow the tablet whole; do not crush, chew, or break.

• Can be taken with or after food to reduce gastrointestinal discomfort.

• Follow the prescribed schedule strictly; abrupt discontinuation may lead to seizures or mood instability.

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Side Effects

Common side effects:

• Nausea, vomiting, or abdominal discomfort

• Drowsiness or dizziness

• Tremors or unsteady movements

• Weight gain

• Hair loss (temporary)

Serious side effects (rare):

• Liver toxicity or abnormal liver function

• Pancreatitis

• Severe allergic reactions (rash, swelling, difficulty breathing)

• Thrombocytopenia (low platelet count)

• Suicidal thoughts or mood changes

Seek immediate medical attention if severe symptoms occur.

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Precautions

• Use cautiously in patients with liver disease, kidney disease, pancreatitis, or metabolic disorders.

• Regular liver function tests and blood counts may be required during treatment.

• Use with caution in pregnancy or breastfeeding, as Divalproex may cause birth defects.

• Avoid alcohol; it can increase drowsiness and risk of side effects.

• Do not stop therapy abruptly without medical supervision.

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Drug Interactions

Divalpro XR 250 Tablet may interact with:

• Other anticonvulsants (Phenytoin, Carbamazepine) – dose adjustment may be needed

• Anticoagulants (Warfarin) – may affect clotting

• NSAIDs or Aspirin – may increase bleeding risk

• Certain antibiotics or antifungals – may alter Divalproex levels

• Sedatives or alcohol – may increase drowsiness

Always inform your doctor about all medications being taken.

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Storage Instructions

• Store below 25°C, in a cool and dry place.

• Protect from light and moisture.

• Keep out of reach of children.

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Key Benefits of Divalpro XR 250 Tablet

• Provides long-lasting seizure control

• Helps stabilize mood in bipolar disorder

• Reduces migraine frequency and severity

• Minimizes peaks and troughs in drug levels for better tolerability

• Convenient once-daily or twice-daily dosing