Grandem Injection

Description

Grandem Injection contains Granisetron (1 mg), a serotonin 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting caused by chemotherapy, radiotherapy, or surgery. It works by blocking serotonin, a natural substance in the body that triggers the vomiting reflex. This medicine is usually administered in a hospital or clinical setting under medical supervision.

Uses / Indications

• Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)

• Prevention and treatment of radiotherapy-induced nausea and vomiting

• Prevention and treatment of post-operative nausea and vomiting (PONV)

How It Works (Mechanism of Action)

• Granisetron (1 mg): Selectively blocks 5-HT3 receptors located in the brain and gastrointestinal tract.

• Prevents serotonin from binding to these receptors, thereby suppressing the vomiting reflex.

• Provides effective relief from nausea and vomiting associated with cancer treatments and surgical procedures.

Dosage & Administration

• Given intravenously (IV) by a doctor or nurse.

• Chemotherapy-induced nausea/vomiting: Usually administered before and/or after chemotherapy.

• Surgery-related nausea/vomiting: Administered before induction of anesthesia or after surgery if nausea occurs.

• Dose and frequency are determined by the doctor depending on the patient’s condition, type of chemotherapy/surgery, and response.

Side Effects

Common:

• Headache

• Constipation

• Diarrhea

• Weakness or fatigue

Less common:

• Dizziness

• Trouble sleeping

• Injection site reactions (pain, redness, swelling)

Serious (rare):

• Allergic reactions (rash, itching, swelling of face/lips, difficulty breathing)

• Heart rhythm disturbances (QT prolongation, palpitations)

• Severe abdominal pain or persistent constipation

Precautions & Warnings

• Should only be administered under medical supervision.

• Caution in patients with heart disease or arrhythmias.

• Inform doctor if taking other medicines that affect heart rhythm (e.g., antiarrhythmics, antidepressants).

• Safe use in pregnancy and breastfeeding has not been fully established – use only if prescribed.

• Not recommended for patients with known hypersensitivity to Granisetron or other 5-HT3 antagonists.

Summary

Grandem Injection (Granisetron 1 mg) is an effective anti-nausea medicine used to prevent and manage nausea and vomiting associated with chemotherapy, radiotherapy, and surgical procedures. It is generally well-tolerated, but requires hospital/clinical administration and monitoring for possible side effects like headache, constipation, or heart rhythm changes.