Grandem Injection

Description

Grandem Injection contains Granisetron (1 mg), a 5-HT3 receptor antagonist that helps in preventing and treating nausea and vomiting. It is widely used in patients undergoing chemotherapy, radiotherapy, or surgical procedures, where these side effects are common. The injection is usually administered in a hospital or clinic under medical supervision for fast and reliable action.

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Uses / Indications

• Prevention of chemotherapy-induced nausea and vomiting (CINV)

• Prevention of radiotherapy-induced nausea and vomiting

• Management of post-operative nausea and vomiting (PONV)

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How It Works (Mechanism of Action)

• Granisetron works by blocking serotonin (5-HT3) receptors in the brain and gut.

• Serotonin is a natural substance responsible for triggering the vomiting reflex.

• By blocking serotonin’s action, the injection helps prevent and relieve nausea and vomiting.

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Dosage & Administration

• Administered intravenously (IV) by a healthcare professional.

• Given before chemotherapy/radiotherapy or before/after surgery depending on the case.

• Dose, frequency, and duration depend on patient’s age, condition, and response to therapy.

• Not self-administered – must be given under medical guidance.

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Side Effects

Common:

• Headache

• Constipation or diarrhea

• Weakness, fatigue

Less common:

• Dizziness

• Trouble sleeping

• Injection site pain, redness, or swelling

Serious (rare):

• Severe allergic reaction (rash, swelling, difficulty breathing)

• Abnormal heart rhythms (QT prolongation, palpitations)

• Severe constipation or abdominal pain

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Precautions & Warnings

• Should only be used under doctor’s supervision.

• Caution in patients with heart disease, arrhythmias, or electrolyte imbalance.

• Inform the doctor about all medicines, especially those affecting heart rhythm (like antiarrhythmics, antidepressants).

• Use in pregnancy or breastfeeding only if clearly prescribed.

• Not suitable for patients allergic to Granisetron or other 5-HT3 antagonists (e.g., Ondansetron).

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Summary

Grandem Injection (Granisetron 1 mg) is an effective anti-nausea and anti-vomiting medicine commonly used in chemotherapy, radiotherapy, and surgical patients. It is well-tolerated but must be given in a hospital/clinic setting to ensure safety and effectiveness, with monitoring for rare but serious side effects.