Grandem MD Tablet

Description

Grandem MD Tablet contains Granisetron (1mg), a 5-HT3 receptor antagonist widely prescribed to prevent and treat nausea and vomiting associated with chemotherapy, radiotherapy, and post-operative recovery.
The MD (Mouth Dissolving) form allows the tablet to dissolve quickly on the tongue without the need for water, making it convenient for patients who experience nausea and difficulty swallowing.

---

Uses / Indications

• Chemotherapy-induced nausea and vomiting (CINV)

• Radiotherapy-induced nausea and vomiting (RINV)

• Post-operative nausea and vomiting (PONV)

---

How It Works

• Chemotherapy, radiotherapy, or surgery can trigger serotonin release in the gut.

• Serotonin binds to 5-HT3 receptors in the brain and gut, causing vomiting.

• Granisetron blocks these receptors, preventing nausea and vomiting signals from reaching the brain.

---

Dosage & Administration

• Usually 1 tablet (1mg) is taken 1 hour before chemotherapy/radiotherapy.

• Can also be given before and after surgery.

• The MD formulation dissolves on the tongue; no water is needed.

• Exact dosage and schedule should be determined by the doctor based on treatment and patient condition.

---

Side Effects

Common:

• Headache

• Constipation

• Diarrhea

• Fatigue or drowsiness

Less Common:

• Dizziness

• Abdominal discomfort

• Sleep disturbances

Serious (rare):

• Allergic reactions (rash, swelling, difficulty breathing)

• Irregular heartbeat (QT prolongation)

• Severe constipation

---

Precautions & Warnings

• Avoid use if allergic to Granisetron or other 5-HT3 antagonists.

• Caution in patients with heart disease, electrolyte imbalance, or liver impairment.

• Pregnant or breastfeeding women should use only if prescribed.

• May cause mild drowsiness – avoid driving until you know how it affects you.

---

Summary

Grandem MD Tablet (Granisetron 1mg) is a fast-dissolving antiemetic that provides convenient relief from nausea and vomiting caused by cancer treatments or surgery. Its mouth-dissolving form makes it especially useful for patients who cannot swallow conventional tablets due to ongoing nausea.