Description
ITROMED-SB 65 contains itraconazole 65 mg formulated using SUBA (SUper-BioAvailable) technology. This special pharmaceutical technology enhances bioavailability by using a solid dispersion of itraconazole in a polymer matrix, resulting in superior absorption compared to conventional crystalline itraconazole capsules.
SUBA Technology Benefits
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Enhanced bioavailability: The 65 mg SUBA formulation provides equivalent therapeutic effect to higher doses of conventional itraconazole.
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Consistent absorption: Less dependent on stomach acid and food intake for absorption.
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Reduced variability: More predictable plasma levels between patients and doses.
Uses
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Superficial fungal infections: Ringworm, athlete’s foot, jock itch caused by Trichophyton, Microsporum, and Epidermophyton species.
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Nail infections (onychomycosis): Persistent fungal infections of fingernails and toenails.
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Mucosal candidiasis: Vaginal yeast infections, oral/throat thrush, especially in immunocompromised patients.
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Systemic mycoses: Cryptococcal infections, histoplasmosis, aspergillosis, blastomycosis.
Mechanism of Action
Itraconazole blocks ergosterol synthesis by inhibiting the fungal enzyme lanosterol 14α-demethylase, disrupting the fungal cell membrane and causing cell death.
Common Side Effects
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Nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, constipation, dyspepsia.
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Rare but serious: severe skin reactions, liver toxicity, heart rhythm abnormalities.
Directions & Precautions
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Take with food for optimal absorption.
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Avoid antacids for 2 hours after dosing (or take with cola if antacids necessary).
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Complete full course even if symptoms improve early.
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Monitor liver function for treatments longer than one month.
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Not recommended in pregnancy, heart failure, or severe liver/kidney disease.
ITROMED-SB 65 is a prescription antifungal with enhanced bioavailability technology, widely available in India.
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