Description
Ornof Tablet is a combination antibiotic containing Ofloxacin, a fluoroquinolone, and Ornidazole, an antiprotozoal and antibacterial agent. This dual-action formulation is used to treat mixed bacterial and protozoal infections, particularly in the gastrointestinal and genitourinary tracts.
Uses
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Gastrointestinal infections – amoebic dysentery, giardiasis, enteritis
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Urinary tract infections (UTIs)
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Bacterial diarrhea and dysentery
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Mixed protozoal and bacterial infections
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Genitourinary infections (e.g., trichomoniasis, bacterial vaginosis)
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Other susceptible bacterial infections where combination therapy is required
How It Works
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Ofloxacin (200mg): Inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial replication and growth.
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Ornidazole (500mg): Interferes with DNA synthesis in protozoa and anaerobic bacteria, causing cell death.
The combination provides broad-spectrum coverage for both bacterial and protozoal infections.
Side Effects
Common:
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Nausea, vomiting
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Stomach discomfort or diarrhea
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Headache, dizziness
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Metallic taste in the mouth
Serious (rare):
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Severe allergic reactions (rash, swelling, difficulty breathing)
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Tendonitis or tendon rupture (linked to Ofloxacin)
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Peripheral neuropathy or neurological symptoms (linked to Ornidazole)
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Liver enzyme elevation
Precautions
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Avoid in patients allergic to fluoroquinolones or nitroimidazoles
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Use with caution in renal or hepatic impairment
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Avoid in pregnancy and breastfeeding unless prescribed
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Avoid alcohol during treatment and for 48 hours after completion
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May cause photosensitivity – avoid excessive sun exposure
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Not recommended for children and adolescents unless specifically prescribed
Administration
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Taken orally, usually twice daily or as prescribed by a doctor
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Can be taken with or without food
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Complete the full prescribed course to prevent recurrence or resistance
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