TENEPLA M 1000

Description

Tenepla-M 1000 Tablet is an oral antidiabetic combination medicine manufactured by Cipla Ltd. It is prescribed for the management of Type 2 Diabetes Mellitus when diet, exercise, and monotherapy do not provide adequate control.

It combines:

• Teneligliptin (20mg): A DPP-4 inhibitor that enhances incretin hormones (GLP-1 and GIP). This results in increased insulin release from the pancreas and reduced glucagon secretion, especially after meals, thereby lowering blood glucose levels.

• Metformin (1000mg): A biguanide that reduces glucose production in the liver, improves insulin sensitivity, and slows down glucose absorption from the intestine.

This dual mechanism ensures effective control of fasting blood glucose (FPG) and postprandial blood glucose (PPG), leading to improved HbA1c outcomes.

Uses of Tenepla-M 1000 Tablet

• Management of Type 2 Diabetes Mellitus in adults.

• Improves both short-term and long-term glycemic control.

• Helps prevent complications of diabetes such as kidney damage, nerve damage, vision problems, and cardiovascular diseases.

• Suitable for patients requiring stronger glycemic control compared to lower Metformin doses.

How Tenepla-M 1000 Works

1. Teneligliptin (20mg): Prolongs the action of incretin hormones, which stimulate insulin secretion in a glucose-dependent manner and suppress glucagon release.

2. Metformin (1000mg): Reduces hepatic glucose output, enhances peripheral glucose uptake, and decreases intestinal absorption of glucose.

Together, they provide complementary action for stable and effective blood sugar management.

Dosage & Administration

• Usually taken once or twice daily, as directed by the physician.

• Best taken with meals to reduce gastrointestinal side effects from Metformin.

• Regular monitoring of blood sugar and HbA1c is advised.

Precautions

• Not for use in Type 1 Diabetes Mellitus or diabetic ketoacidosis.

• Should be used cautiously in patients with kidney or liver problems.

• Avoid alcohol as it increases the risk of lactic acidosis (rare but serious).

• Not recommended in severe heart failure.

• Use in pregnancy and breastfeeding should be under medical supervision.

Possible Side Effects

• Nausea, vomiting, abdominal discomfort, diarrhea (commonly due to Metformin)

• Headache, dizziness

• Hypoglycemia (especially if combined with other antidiabetic agents)

• Sore throat, mild infections (nasopharyngitis)

• Rare: Lactic acidosis, liver enzyme changes, allergic reactions

Overall Benefit

Tenepla-M 1000 Tablet is an effective combination therapy for Type 2 Diabetes, especially for patients who need stronger sugar control. By combining Teneligliptin and a higher dose of Metformin, it helps maintain stable glucose levels, reduces long-term complications, and improves overall quality of life.