TENEPLA M 500

Description

Tenepla-M 500 Tablet is a combination oral antidiabetic medicine manufactured by Cipla Ltd. It contains two active ingredients:

• Teneligliptin (20mg): A DPP-4 inhibitor that enhances incretin hormones, helping the pancreas release more insulin and reducing excessive glucose production in the liver.

• Metformin (500mg): A biguanide that lowers sugar levels by reducing hepatic glucose production, improving insulin sensitivity, and slowing intestinal glucose absorption.

This dual action provides better glycemic control compared to monotherapy and helps manage Type 2 Diabetes Mellitus effectively.

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Uses of Tenepla-M 500 Tablet

• Treatment of Type 2 Diabetes Mellitus in adults.

• Improves control of both fasting blood glucose (FPG) and postprandial glucose (PPG).

• Reduces the risk of long-term diabetes complications such as kidney disease, neuropathy, retinopathy, and cardiovascular events.

• Suitable when diet, exercise, or single drug therapy alone is not sufficient.

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How Tenepla-M 500 Works

1. Teneligliptin (20mg): Blocks the DPP-4 enzyme, prolonging incretin action (GLP-1 & GIP), which increases insulin secretion and lowers glucagon release after meals.

2. Metformin (500mg): Decreases liver glucose output, increases peripheral glucose utilization, and reduces gut glucose absorption.

Together, they provide complementary mechanisms for optimal sugar control.

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Dosage & Administration

• Usually taken once or twice daily, as prescribed by the doctor.

• Should be taken with meals to minimize gastrointestinal side effects.

• Regular monitoring of blood sugar and HbA1c is recommended.

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Precautions

• Not suitable for Type 1 Diabetes or diabetic ketoacidosis.

• Use cautiously in patients with kidney or liver impairment (dose adjustment may be required).

• Avoid in cases of severe heart failure, lactic acidosis, or heavy alcohol consumption.

• Pregnant and breastfeeding women should use only under medical supervision.

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Possible Side Effects

• Nausea, vomiting, diarrhea, abdominal pain (mostly due to Metformin)

• Headache, dizziness

• Hypoglycemia (more likely if combined with other antidiabetic agents)

• Sore throat, mild infections (nasopharyngitis)

• Rare: Lactic acidosis (serious but uncommon), liver enzyme changes, allergic reactions

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Overall Benefit

Tenepla-M 500 Tablet is a powerful and convenient combination therapy for Type 2 Diabetes. It helps maintain long-term glycemic control, reduces diabetes-related complications, and provides the benefit of dual action with a low risk of hypoglycemia and weight neutrality.