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Category: Medicines

PRULOFORD-2

PRULOFORD-2 contains prucalopride 2 mg, a selective serotonin 5-HT4 receptor agonist, used for the management of chronic idiopathic constipation (CIC) in adults when laxatives have failed. The medicine comes in film-coated tablet form and is supplied in convenient strips.

Clinical Uses

  • Indicated for chronic idiopathic constipation in adults, especially when conventional laxatives do not provide adequate relief.

  • Improves bowel movement frequency and completeness.

  • Sometimes prescribed in irritable bowel syndrome with constipation (IBS-C), as directed by a physician.

Mechanism of Action

Prucalopride selectively stimulates 5-HT4 receptors in the gut, enhancing peristalsis (bowel muscle contractions), resulting in increased gut motility and bowel evacuation. It acts by promoting the release of acetylcholine in intestinal nerves.

Dosage & Administration

  • Usual adult dose: 2 mg once daily, with or without food, preferably at the same time each day.

  • Swallow whole with water; do not crush/chew.

  • Duration: Continue for as long as advised; do not exceed dose or stop abruptly without medical guidance.

Common Side Effects

  • Headache, abdominal pain, nausea, diarrhea, decreased appetite, dizziness, or indigestion.

  • Most side effects lessen with continued use, but medical advice is needed if they persist or become severe.

Precautions & Safety Advice

  • Use cautiously in severe liver or kidney disease—requires dose adjustment.

  • Not for use during pregnancy/breastfeeding unless advised by a doctor.

  • Do not use in children under 18 years.

  • If constipation remains unimproved after 4 weeks, consult your doctor for reassessment.

PRULOFORD-2 is a targeted, prescription prokinetic for adults with tough-to-manage chronic constipation.

Quik Kool Gel

Overview and Uses:
Quik Kool Gel is a topical cooling gel designed to provide instant relief from muscle pain, minor burns, insect bites, and skin irritation. Its cooling agents, including Menthol and Aloe Vera, soothe the skin, reduce redness, and give a refreshing sensation.

It is commonly used for:

  • Muscle aches and pains

  • Minor burns or sunburns

  • Insect bites and stings

  • Skin irritation, redness, or itching

  • Providing instant cooling and soothing effect

Dosage and Administration:

  • Apply a thin layer to the affected area

  • Gently massage until absorbed

  • Can be used 2–3 times daily or as needed

  • Avoid covering with tight bandages immediately after application

Precautions and Safety Advice:

  • For external use only

  • Avoid contact with eyes, mouth, and mucous membranes

  • Discontinue if irritation, rash, or allergic reaction occurs

  • Not suitable for broken skin, deep wounds, or severe burns

  • Store in a cool, dry place, away from direct sunlight

Possible Side Effects:

  • Mild skin irritation or tingling at the application site

  • Rare allergic reactions such as rash or redness

Conclusion:
Quik Kool Gel provides fast-acting relief from minor pain, burns, and skin irritation. Its combination of Menthol, Aloe Vera, and cooling agents delivers a soothing and refreshing effect, making it ideal for everyday use in households and for sports or outdoor activities.

QUTIDEP-100 SR

QUTIDEP-100 SR contains quetiapine 100 mg in a sustained release (SR) formulation—an atypical antipsychotic used for prolonged, steady effect in various psychiatric disorders. It is supplied in a blister pack for once- or twice-daily oral dosing.

Clinical Uses

  • Schizophrenia: Treatment of delusions, auditory/visual hallucinations, disorganized thoughts, and social withdrawal.

  • Bipolar disorder: Control of mania, hypomania, depressive episodes, and as a mood stabilizer for long-term prevention of recurrence.

  • Mania: Used in acute episodes and for maintenance.

  • Adjunctive therapy in major depressive disorder (in select cases).

Mechanism of Action

Quetiapine works as a dopamine and serotonin receptor antagonist, rebalancing neurotransmitters in the brain. This leads to improvements in psychosis, mood fluctuation, and behavioral disturbances.

Dosage & Administration

  • Usually started at 50–100 mg daily with slow dose titration based on response and side effects.

  • SR (sustained release) formulation is generally taken once daily, in the evening or as advised; swallow whole, do not crush or chew.

  • Dose adjustments are made by the psychiatrist, with higher maintenance doses for severe illness (up to 800 mg/day).

Common Side Effects

  • Drowsiness, dizziness, dry mouth, constipation, increased appetite, weight gain, orthostatic hypotension (drop in BP with standing), fatigue.

  • Monitor for metabolic changes: increases in cholesterol, triglycerides, blood sugar.

  • Rare: abnormal movements (tardive dyskinesia), severe mood changes, neuroleptic malignant syndrome.

Precautions & Safety Advice

  • Use caution in elderly, diabetes, heart disease, and those with liver impairment.

  • May cause sedation—avoid hazardous activity until effects are known.

  • Regular follow-up for metabolic, heart, and blood profile monitoring is recommended for long-term therapy.

QUTIDEP-100 SR is a prescription sustained-release antipsychotic tablet for round-the-clock management of schizophrenia, bipolar disorder, and mania.

QUTIDEP-25

QUTIDEP-25 contains quetiapine 25 mg, an atypical antipsychotic medication used mainly in psychiatric and neurological conditions. It is supplied in a convenient blister pack for oral administration.

Clinical Uses

  • Treatment of schizophrenia (delusions, hallucinations, disorganized thinking).

  • Acute and maintenance therapy in bipolar disorder (manic and depressive episodes, mood stabilization).

  • Adjunctive therapy in major depressive disorder (in combination with antidepressants, if prescribed by doctor).

Mechanism of Action

Quetiapine works by balancing neurotransmitters (dopamine and serotonin) in the brain. This effect relieves psychosis, stabilizes mood swings, and decreases agitation or anxiety in psychiatric conditions.

Dosage & Administration

  • Initial adult dose is typically 25 mg once or twice daily; the dose is gradually increased per clinical need and response.

  • Can be taken with or without food; swallow whole with water.

  • Dose adjustments are made by the physician depending on indication—maintenance doses usually much higher than 25 mg (often 150–800 mg/day in divided doses for schizophrenia/bipolar disorder).

  • Elderly and those with liver impairment may start at a lower dose.

Common Side Effects

  • Drowsiness, dry mouth, dizziness, weakness, orthostatic hypotension (drop in blood pressure on standing), constipation, increased appetite, weight gain.

  • Rare but serious: movement disorders (tardive dyskinesia), high blood sugar, cholesterol abnormality, altered heart rhythm.

Precautions & Safety Advice

  • Use with caution in elderly, diabetics, and those with heart or liver disease.

  • May impair alertness—do not drive or operate machinery until familiar with effects.

  • Regular monitoring advised for prolonged use—blood sugar, cholesterol, heart function.

QUTIDEP-25 is a prescription antipsychotic for psychiatric stabilization in schizophrenia, bipolar disorder, and adjunct in depression.

QUTIDEP-50

QUTIDEP-50 contains quetiapine 50 mg, an atypical antipsychotic used to treat a variety of psychiatric conditions. It is supplied in a blister pack for oral use.

Clinical Uses

  • Schizophrenia: For management of delusions, hallucinations, and disordered thought.

  • Bipolar disorder: Used for both manic and depressive episodes and as a long-term mood stabilizer.

  • Adjunct in major depressive disorder (in combination with antidepressants, if prescribed by your psychiatrist).

Mechanism of Action

Quetiapine balances dopamine and serotonin activity in the brain, reducing psychosis, stabilizing mood, and lessening agitation or anxiety.

Dosage & Administration

  • Initial dose for adults often starts at 50 mg, with gradual increases based on clinical response.

  • Dose adjustments are made by the physician. Maintenance doses for serious illness (schizophrenia, bipolar) are usually much higher than 50 mg (commonly 150–800 mg per day in divided doses).

  • Swallow whole, with or without food.

  • Elderly and patients with liver disease may require lower starting doses.

Common Side Effects

  • Drowsiness, dry mouth, weight gain, dizziness, constipation, low blood pressure.

  • Less common but serious: movement disorders (tardive dyskinesia), blood sugar or cholesterol changes, abnormal heart rhythm, mood or behavioral changes.

Precautions & Safety Advice

  • Use with caution in elderly, diabetics, or those with cardiovascular/liver issues.

  • May impair alertness—do not drive or operate machinery until personal response is known.

  • Regular monitoring of weight, blood sugar, and cholesterol is advised for long-term therapy.

QUTIDEP-50 is a prescription tablet for the management of major psychiatric disorders, including schizophrenia, bipolar disorder, and adjunctive use in depression.

Rabemac 20 Tablet

Rabemac 20 Tablet contains Rabeprazole (20mg), a medicine that belongs to the class of proton pump inhibitors (PPIs). It works by reducing the amount of acid produced in the stomach, providing relief from acid-related conditions.

It is commonly prescribed for acid reflux, heartburn, ulcers, and gastroesophageal reflux disease (GERD). By lowering stomach acid, Rabemac not only relieves discomfort but also helps the healing of ulcers and prevents further damage to the food pipe (esophagus).

Uses

Rabemac 20 Tablet is prescribed for:

  • Gastroesophageal reflux disease (GERD)

  • Acid reflux and heartburn

  • Stomach and duodenal ulcers

  • Zollinger–Ellison syndrome (rare condition with excessive stomach acid)

  • Prevention of ulcers caused by long-term NSAID (painkiller) use

Advantages

  • Provides fast and effective relief from acidity and heartburn.

  • Promotes healing of ulcers in the stomach and intestine.

  • Protects the esophagus from acid-related damage.

  • Effective with once-daily dosing in most patients.

  • Well-tolerated compared to older acid-reducing medicines.

Possible Side Effects

Common and usually mild side effects include:

  • Headache

  • Nausea, vomiting, diarrhea

  • Stomach pain, gas, constipation

  • Dizziness

👉 Rare but serious side effects (need medical attention):

  • Severe allergic reactions (rash, swelling, difficulty breathing)

  • Low magnesium levels (muscle cramps, irregular heartbeat) with long-term use

  • Vitamin B12 deficiency or bone weakness (osteoporosis) if used for prolonged periods

Precautions

  • Take the tablet before meals (preferably in the morning) for best results.

  • Inform your doctor if you have liver disease or are taking other medicines for HIV, fungal infections, or blood thinning.

  • Avoid long-term or unnecessary use unless prescribed, as it may increase the risk of infections, fractures, or nutrient deficiencies.

  • Not recommended for immediate relief of acute heartburn; it works gradually.

  • Safe in pregnancy and breastfeeding only if clearly prescribed by the doctor.

Rabemac LS Capsule SR

Rabemac LS Capsule SR is a dual-action medicine that combines Levosulpiride (75mg) and Rabeprazole (20mg).

  • Rabeprazole is a proton pump inhibitor (PPI) that reduces excess stomach acid and helps heal acid-related damage to the stomach and esophagus.

  • Levosulpiride is a prokinetic agent that enhances stomach and intestinal movement, helping in faster gastric emptying and relieving symptoms like bloating, fullness, and reflux.

This combination is highly effective in patients with acid reflux, GERD (gastroesophageal reflux disease), dyspepsia (indigestion), and related conditions.

Uses

Rabemac LS Capsule SR is commonly prescribed for:

  • Gastroesophageal reflux disease (GERD)

  • Acid reflux and persistent heartburn

  • Functional dyspepsia (indigestion, bloating, upper abdominal discomfort)

  • Nausea and vomiting associated with acidity

  • Delayed gastric emptying and reflux-related disorders

Advantages

  • Dual benefit: Reduces acid secretion and improves gut motility.

  • Provides faster and long-lasting relief from acidity, reflux, and indigestion.

  • Prevents regurgitation, bloating, and fullness after meals.

  • Promotes healing of stomach and esophageal lining.

Possible Side Effects

Most side effects are mild and temporary, but may include:

  • Headache, dizziness

  • Nausea, diarrhea, constipation, or abdominal discomfort

  • Mild sleep disturbances or restlessness (due to levosulpiride)

  • Increased prolactin levels (may rarely cause breast enlargement, milk secretion, or menstrual irregularities)

👉 Rare but serious side effects:

  • Severe allergic reactions (rash, swelling, difficulty breathing)

  • Irregular heartbeat or muscle stiffness

  • Low magnesium or vitamin B12 levels with prolonged use

Precautions

  • Take the capsule before meals, preferably in the morning.

  • Use with caution in patients with liver, kidney, or heart conditions.

  • Avoid long-term or unnecessary use unless prescribed, as prolonged levosulpiride may cause hormonal effects.

  • Inform your doctor if you are taking medicines for depression, fungal infections, or heart rhythm problems.

  • Not recommended in pregnancy or breastfeeding unless clearly advised by a doctor.

  • Lifestyle modifications (avoiding spicy food, alcohol, smoking, late-night meals) enhance treatment effectiveness.

Rabemac-DSR Capsule

Rabemac-DSR Capsule is a combination medicine containing Domperidone (30mg) and Rabeprazole (20mg).

  • Rabeprazole is a proton pump inhibitor (PPI) that reduces excess stomach acid.

  • Domperidone is a prokinetic agent that improves stomach emptying and prevents nausea, bloating, and vomiting.

Together, they provide effective relief from acid reflux, GERD (gastroesophageal reflux disease), heartburn, indigestion, and regurgitation. The dual action not only controls acidity but also relieves associated symptoms like nausea, bloating, and discomfort.

Uses

Rabemac-DSR Capsule is commonly prescribed for:

  • Gastroesophageal reflux disease (GERD)

  • Acid reflux and heartburn

  • Indigestion with nausea or bloating

  • Regurgitation (food coming back into the mouth)

  • Stomach discomfort caused by delayed gastric emptying

Advantages

  • Dual-action relief: Controls acidity and reduces nausea/vomiting.

  • Provides faster symptom control compared to Rabeprazole alone.

  • Improves digestion and stomach emptying.

  • Reduces complications of long-term acidity such as esophagitis (inflammation of the food pipe).

Possible Side Effects

Common side effects may include:

  • Headache

  • Diarrhea or constipation

  • Dry mouth, stomach cramps, flatulence

  • Dizziness or sleepiness

👉 Rare but serious side effects:

  • Irregular heartbeat or palpitations (due to Domperidone)

  • Low magnesium or vitamin B12 with prolonged use

  • Severe allergic reactions (rash, swelling, breathing difficulty)

Precautions

  • Take the capsule before meals, preferably in the morning.

  • Avoid use if you have a history of heart problems, liver disease, or stomach bleeding.

  • Should not be taken with certain medicines (like ketoconazole, erythromycin, or antifungals) that may increase Domperidone side effects.

  • Long-term use should be monitored to avoid risks like bone fractures, low magnesium, or vitamin B12 deficiency.

  • Pregnant and breastfeeding women should take only if prescribed by a doctor.

RABESEC 20

Rabesec 20 Tablet is a proton pump inhibitor (PPI) used to treat conditions caused by excess stomach acid. It works by blocking the proton pumps in the stomach lining, thereby reducing acid secretion and providing relief from symptoms such as heartburn, acidity, indigestion, and acid reflux.

It is commonly prescribed for Gastroesophageal Reflux Disease (GERD), peptic ulcers, and erosive esophagitis. By lowering stomach acid levels, it also helps in preventing damage to the food pipe (esophagus) caused by acid reflux and promotes healing of ulcers.

Uses

  • Gastroesophageal reflux disease (GERD)

  • Zollinger–Ellison syndrome (excess acid production)

  • Peptic and duodenal ulcers

  • Erosive esophagitis

  • Acid-related indigestion and heartburn

How It Works

  • Rabeprazole (20 mg): Belongs to the PPI class of medicines. It irreversibly inhibits the H+/K+ ATPase enzyme (proton pump) in the stomach lining, which is responsible for acid secretion. This results in long-lasting reduction of stomach acid and relief from acidity and reflux symptoms.

Side Effects

Common side effects may include:

  • Headache, dizziness

  • Diarrhea, constipation, flatulence

  • Abdominal pain, nausea, vomiting

  • Rash or allergic reactions (rare)

  • Long-term use may cause vitamin B12 deficiency, low magnesium levels, or bone weakness

Precautions & Warnings

  • Avoid if allergic to Rabeprazole or other PPIs.

  • Use cautiously in patients with liver disease or osteoporosis.

  • Long-term or high-dose use should be monitored by a doctor.

  • Pregnant and breastfeeding women should use only under medical advice.

  • Avoid alcohol and smoking as they can worsen acid reflux.

Dosage & Administration

  • Usual dose: 20 mg once daily before meals, or as directed by the physician.

  • Tablet should be swallowed whole, not crushed or chewed.

  • Duration of therapy varies depending on the medical condition.

RABESEC D

Rabesec D Tablet is a combination medicine used to treat acid reflux, gastroesophageal reflux disease (GERD), heartburn, acidity, and indigestion. It contains Rabeprazole, a proton pump inhibitor (PPI) that reduces stomach acid, and Domperidone, a prokinetic agent that enhances stomach and intestinal movement, thereby preventing reflux and nausea.

This dual-action formula provides faster relief by controlling acid secretion and improving gastric emptying. It helps in healing acid-related damage to the stomach and esophagus, prevents regurgitation of food, and reduces discomfort caused by bloating, nausea, and belching.

Uses

  • Gastroesophageal reflux disease (GERD)

  • Acid reflux & persistent heartburn

  • Indigestion with bloating or belching

  • Nausea and vomiting associated with acidity

  • Stomach and duodenal ulcers

How It Works

  • Rabeprazole (20 mg): A PPI that suppresses gastric acid secretion by irreversibly blocking the H+/K+ ATPase enzyme (proton pump) in the stomach lining.

  • Domperidone (10 mg): A dopamine antagonist that increases gut motility and prevents reflux by tightening the lower esophageal sphincter.

Together, they reduce stomach acid and improve digestion, giving long-lasting relief from acidity and reflux symptoms.

Side Effects

Some common side effects may include:

  • Headache, dizziness

  • Nausea, vomiting, diarrhea, or constipation

  • Abdominal pain, flatulence

  • Dry mouth

  • Rarely: irregular heartbeat, allergic reactions

Precautions & Warnings

  • Avoid if allergic to Rabeprazole, Domperidone, or other PPIs.

  • Use with caution in patients with heart disease, kidney or liver problems.

  • Not recommended for long-term use without medical supervision.

  • Pregnant or breastfeeding women should consult a doctor before use.

  • Avoid alcohol and spicy food as they may worsen acidity.

Dosage & Administration

  • Typical dose: One tablet daily before meals, or as prescribed by a doctor.

  • Swallow whole with water, do not crush or chew.

  • Duration of treatment depends on the patient’s condition.

RABESEC D SR

RabEsec D SR Capsule is a combination medicine manufactured by Cipla Ltd, designed to treat disorders related to excess stomach acid and poor gastric motility. It contains Rabeprazole (20mg), a proton pump inhibitor, and Domperidone SR (30mg), a prokinetic agent.

Rabeprazole works by blocking acid secretion in the stomach, which provides relief from heartburn, acidity, and gastroesophageal reflux disease (GERD). It also supports the healing of peptic ulcers and erosive esophagitis. Domperidone SR, on the other hand, enhances the movement of food through the digestive tract, thereby reducing symptoms like bloating, nausea, vomiting, and fullness after meals.

This dual action makes RabEsec D SR particularly useful in patients who suffer from acid reflux associated with nausea or delayed stomach emptying.

Uses of RabEsec D SR:

  • Treatment of GERD (gastroesophageal reflux disease)

  • Relief from acidity and heartburn

  • Management of nausea, vomiting, and bloating caused by reflux

  • Healing and prevention of gastric and duodenal ulcers

  • Helpful in indigestion and delayed gastric emptying

Key Benefits:

  • Provides long-lasting relief from acid reflux

  • Prevents regurgitation and heartburn

  • Improves digestion and reduces gastric discomfort

  • Aids in faster healing of stomach lining

Important Information:

  • Should be taken before meals for best results.

  • Swallow the capsule whole, do not chew or crush.

  • Use only under doctor’s supervision, especially in patients with heart, liver, or kidney conditions.

  • Long-term use may require monitoring of vitamin B12, calcium, and magnesium levels.

  • Not advised during pregnancy or breastfeeding unless recommended by a doctor.

RABESEC LS

RabEsec LS Capsule is a combination medicine manufactured by Cipla Ltd. It is formulated with two active ingredients – Rabeprazole (20mg), a proton pump inhibitor (PPI), and Levosulpiride (75mg), a prokinetic agent belonging to the substituted benzamide class. This dual-action formula makes it highly effective in treating acid-related gastrointestinal disorders where both acid suppression and improved stomach motility are required.

  • Rabeprazole acts by irreversibly blocking the H+/K+ ATPase (proton pump) in the stomach lining. This results in a marked reduction in stomach acid secretion, providing long-lasting relief from acidity, heartburn, and acid reflux. By lowering gastric acid levels, it also allows the stomach and esophagus to heal from ulcers and erosions caused by excess acid.

  • Levosulpiride is a prokinetic agent that works by enhancing gastrointestinal motility and increasing the release of acetylcholine. It stimulates the movement of the stomach and intestines, ensuring faster emptying of food and reducing symptoms like bloating, indigestion, nausea, and fullness after meals. In addition, Levosulpiride has mild antiemetic properties that help prevent vomiting and regurgitation related to reflux.

Therapeutic Uses of RabEsec LS:

  • Gastroesophageal Reflux Disease (GERD): Provides effective relief from acid reflux, heartburn, and regurgitation.

  • Functional Dyspepsia (Indigestion): Relieves discomfort, bloating, and a heavy feeling after meals.

  • Peptic Ulcer Disease: Helps in healing gastric and duodenal ulcers caused by excess acid.

  • Esophagitis: Promotes healing of inflammation in the esophagus due to acid exposure.

  • Nausea and Vomiting: Prevents symptoms associated with delayed gastric emptying and acid reflux.

Key Benefits:

  • Dual-action medicine: reduces acid and improves stomach motility.

  • Provides quick and sustained relief from acidity and heartburn.

  • Improves digestion by preventing delayed gastric emptying.

  • Heals stomach and esophageal lining from acid-related damage.

  • Reduces regurgitation, nausea, and discomfort after eating.

Dosage & Administration:

  • The capsule is usually taken once daily, before meals, or as directed by the physician.

  • Swallow the capsule whole with water. Do not chew, break, or crush it.

  • The duration of treatment depends on the severity of the condition and the doctor’s recommendation.

Safety Advice & Precautions:

  • Should be taken only under medical supervision.

  • Not recommended in patients with severe liver, kidney, or heart disorders unless prescribed.

  • Long-term use of Rabeprazole may lead to vitamin B12, calcium, and magnesium deficiencies, hence monitoring may be required.

  • Levosulpiride should be used cautiously in patients with neurological disorders, movement disorders, or psychiatric illness.

  • Avoid alcohol and smoking as they may worsen acidity and reduce the effectiveness of treatment.

  • Not recommended during pregnancy and breastfeeding unless prescribed by a doctor.