Description
Gabamax SR 75 Tablet is a combination medicine used in the treatment of neuropathic pain and related nerve disorders. It contains Pregabalin, an antiepileptic drug with strong pain-relieving and anxiolytic properties, and Methylcobalamin (Vitamin B12), which supports nerve repair and regeneration.
The SR (Sustained Release) formulation ensures that the medicine is released slowly and steadily into the body, providing long-lasting relief and improving patient compliance by reducing dosing frequency.
Uses / Indications
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Neuropathic pain (caused by diabetes, shingles, spinal cord injury, or nerve damage)
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Peripheral neuropathy
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Postherpetic neuralgia (pain after shingles infection)
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Fibromyalgia (widespread musculoskeletal pain and fatigue)
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Adjunct therapy in partial seizures
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Nerve regeneration in vitamin B12 deficiency
How It Works (Mechanism of Action)
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Pregabalin (75 mg):
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Binds to calcium channels in the central nervous system.
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Decreases the release of pain-related neurotransmitters such as glutamate, noradrenaline, and substance P.
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Provides analgesic, anticonvulsant, and anti-anxiety effects.
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Methylcobalamin (1500 mcg):
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An active form of Vitamin B12.
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Promotes nerve repair, myelin sheath formation, and regeneration of damaged neurons.
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Improves overall nerve function and conduction.
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Together, the combination not only reduces nerve pain but also helps in long-term nerve healing.
Dosage & Administration
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Typical adult dose: One tablet daily, or as prescribed.
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Should be swallowed whole with water, preferably at the same time each day.
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Can be taken with or without food.
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Dose adjustments may be required in patients with kidney problems or in elderly patients.
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Do not stop suddenly; tapering may be needed to avoid withdrawal symptoms.
Side Effects
Common:
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Drowsiness, dizziness, sleepiness
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Blurred vision, headache
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Weight gain, swelling in hands/feet
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Dry mouth, constipation
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Fatigue or difficulty concentrating
Serious (rare):
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Severe allergic reaction (rash, swelling, difficulty breathing)
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Mood changes, depression, suicidal thoughts
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Heart rhythm disturbances
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Breathing difficulties (especially in patients with lung disease)
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Severe muscle weakness
Precautions & Warnings
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May cause drowsiness and dizziness → avoid driving or operating heavy machinery.
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Should be used cautiously in patients with kidney disease, heart problems, or psychiatric illness.
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Alcohol should be avoided as it may increase sedation and dizziness.
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May increase the risk of suicidal thoughts → monitor mood and behavior changes.
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Safe use in pregnancy and breastfeeding should only be under medical supervision.
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Not intended for use in children unless prescribed.
Summary
Gabamax SR 75 Tablet (Methylcobalamin 1500 mcg + Pregabalin 75 mg) is a nerve-protective and pain-relieving medicine designed for the long-term management of neuropathic pain and nerve disorders. Its sustained release action provides prolonged relief, making it highly effective for patients with chronic conditions like diabetic neuropathy, postherpetic neuralgia, and fibromyalgia. While effective, it requires careful monitoring due to potential side effects such as drowsiness, mood changes, and weight gain.
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