Description
GTN Sorbitrate CR 6.4 Tablet is a controlled-release (CR) formulation of Nitroglycerin (6.4mg), a nitrate vasodilator widely prescribed for the prevention and long-term management of angina pectoris (chest pain caused by reduced blood flow to the heart muscle).
The controlled-release form ensures a slow and sustained release of the drug, providing prolonged action and reducing the frequency of angina attacks compared to immediate-release formulations.
It works by relaxing blood vessels, reducing the strain on the heart, and improving oxygen delivery to heart muscles.
Uses:
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Prevention and management of chronic stable angina.
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Reduces the frequency and severity of chest pain episodes.
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Improves exercise capacity in patients with ischemic heart disease.
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May be part of therapy in patients with coronary artery disease (CAD).
Dosage & Administration:
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Dosage must be as prescribed by the doctor.
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Typically taken once or twice daily, depending on severity.
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Should be swallowed whole with water; do not chew, crush, or break the tablet.
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Not suitable for immediate relief of acute angina attacks (for emergencies, sublingual nitroglycerin tablets are used).
Mechanism of Action:
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Nitroglycerin is converted into nitric oxide (NO) inside the body.
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NO activates guanylate cyclase, increasing cyclic GMP (cGMP) in vascular smooth muscles.
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This causes vasodilation (widening of blood vessels), reducing:
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Preload (blood returning to the heart).
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Afterload (resistance against which the heart pumps).
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The net result: decreased oxygen demand and better oxygen supply to heart muscles, preventing angina.
Side Effects:
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Common: Headache, dizziness, flushing, weakness, hypotension (low blood pressure).
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Less common: Palpitations, nausea, blurred vision, fatigue.
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Serious but rare: Severe hypotension, fainting, methemoglobinemia, tolerance (reduced effect with continuous use).
Precautions:
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Not indicated for acute angina attack relief.
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Must not be stopped suddenly; tapering is required under medical supervision.
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Caution in patients with:
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Low blood pressure
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Severe anemia
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History of glaucoma
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Recent head injury or brain trauma
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Avoid alcohol as it may intensify the blood pressure-lowering effect.
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Contraindicated with phosphodiesterase-5 inhibitors (like sildenafil, tadalafil, vardenafil) due to risk of a dangerous drop in blood pressure.
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Use with caution in pregnancy and breastfeeding—only under medical advice.
Storage:
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Store in a cool, dry place, away from direct heat and moisture.
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Keep the container tightly closed.
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Keep away from children.
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