Description
Megagliptin MF Forte Tablet is a combination oral antidiabetic medication used to manage type 2 diabetes mellitus. It contains:
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Metformin (1000mg): A biguanide that reduces hepatic glucose production, increases insulin sensitivity, and improves peripheral glucose uptake.
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Teneligliptin (20mg): A DPP-4 inhibitor that enhances incretin hormone levels, increasing insulin secretion and reducing glucagon production in a glucose-dependent manner.
This combination provides complementary mechanisms of action, improving blood glucose control more effectively than either drug alone.
Uses / Indications
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Type 2 diabetes mellitus in adults
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Inadequate glycemic control with metformin or teneligliptin monotherapy
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Can be used as part of combination therapy with diet and exercise to improve blood sugar levels
How It Works
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Metformin reduces glucose production in the liver and increases peripheral glucose uptake.
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Teneligliptin inhibits DPP-4 enzyme, increasing GLP-1 and GIP hormones to enhance insulin release and reduce glucagon secretion.
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Together, they provide better glycemic control while minimizing the risk of hypoglycemia.
Dosage & Administration
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Usually taken once or twice daily, with meals to reduce gastrointestinal side effects.
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Swallow the tablet whole with water.
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Dosage adjustments may be necessary in renal or hepatic impairment.
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Regular monitoring of blood glucose and HbA1c is recommended.
Side Effects
Common:
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Nausea, vomiting, or mild stomach upset
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Diarrhea or bloating
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Mild headache
Less Common / Rare:
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Hypoglycemia (especially when used with sulfonylureas or insulin)
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Skin rash or itching
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Dizziness
Serious (rare):
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Lactic acidosis (rare, associated with metformin)
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Pancreatitis (rare, associated with DPP-4 inhibitors)
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Severe hepatic dysfunction
Precautions & Warnings
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Avoid in patients with renal failure, liver disease, or severe heart conditions.
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Use caution in elderly patients and those at risk of lactic acidosis.
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Monitor blood sugar when combined with other antidiabetic drugs to prevent hypoglycemia.
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Pregnant or breastfeeding women should use only if prescribed by a doctor.
Summary
Megagliptin MF Forte Tablet (Metformin 1000mg + Teneligliptin 20mg) is a combination antidiabetic drug that improves glycemic control through dual mechanisms: reducing hepatic glucose production and enhancing insulin secretion. It is suitable for adult patients with type 2 diabetes, and should be used under medical supervision with regular monitoring.
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