Megagliptin MF Tablet

Description

Megagliptin MF Tablet is a combination oral antidiabetic medication used to manage type 2 diabetes mellitus. It contains:

• Metformin (500mg): A biguanide that reduces hepatic glucose production, improves insulin sensitivity, and enhances peripheral glucose uptake.

• Teneligliptin (20mg): A DPP-4 inhibitor that increases incretin hormone levels, promoting insulin secretion and suppressing glucagon release in a glucose-dependent manner.

This combination offers complementary mechanisms of action, helping to achieve better glycemic control than either drug alone.

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Uses / Indications

• Type 2 diabetes mellitus in adults

• Patients with inadequate glycemic control on metformin or teneligliptin monotherapy

• Part of a combined therapy with diet and exercise to manage blood sugar levels

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How It Works

• Metformin decreases glucose production by the liver and improves peripheral glucose utilization.

• Teneligliptin inhibits DPP-4, preventing the breakdown of GLP-1 and GIP, thereby increasing insulin release and decreasing glucagon secretion.

• Together, they provide improved glycemic control with minimal risk of hypoglycemia.

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Dosage & Administration

• Usually taken once or twice daily, with meals to reduce gastrointestinal discomfort.

• Swallow the tablet whole with water.

• Dose adjustment may be needed in renal or hepatic impairment.

• Regular monitoring of blood glucose and HbA1c is recommended.

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Side Effects

Common:

• Nausea, vomiting, or mild stomach upset

• Diarrhea or bloating

• Mild headache

Less Common / Rare:

• Hypoglycemia (especially if combined with sulfonylureas or insulin)

• Skin rash or itching

• Dizziness

Serious (rare):

• Lactic acidosis (rare, associated with metformin)

• Pancreatitis (rare, associated with DPP-4 inhibitors)

• Severe hepatic dysfunction

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Precautions & Warnings

• Avoid in patients with renal failure, liver disease, or severe heart conditions.

• Use caution in elderly patients and those at risk of lactic acidosis.

• Monitor blood sugar when combined with other antidiabetic drugs to prevent hypoglycemia.

• Pregnant or breastfeeding women should use only if prescribed by a doctor.

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Summary

Megagliptin MF Tablet (Metformin 500mg + Teneligliptin 20mg) is a dual-action antidiabetic medication for type 2 diabetes. It helps control blood glucose by reducing hepatic glucose production and enhancing insulin secretion. The tablet should be used under medical supervision with regular monitoring for optimal results.