Category: ANTI - DIABETIC

CIPDAPLA-M 10/1000 Tablet is a combination anti-diabetic medicine used in the management of Type 2 Diabetes Mellitus. It combines the actions of two well-established molecules:

• Dapagliflozin (10mg): A sodium-glucose co-transporter 2 (SGLT2) inhibitor. It lowers blood sugar by promoting the removal of excess glucose through urine, acting independently of insulin.

• Metformin Hydrochloride (1000mg): A biguanide. It reduces liver glucose production, improves insulin sensitivity, and decreases the absorption of glucose from the intestines.

Mechanism of Action

• Together, these ingredients decrease blood sugar more effectively than metformin alone. Dapagliflozin increases glucose excretion, while metformin reduces the amount of new glucose produced and improves the body’s response to its own insulin.

• The combination can also help reduce the risk of cardiovascular events (such as heart attacks and heart failure) in patients with diabetes and high cardiovascular risk.

Indications

• Type 2 Diabetes Mellitus: Particularly when monotherapy (single-agent treatment) does not suffice in achieving glycemic control.

• Prevention of long-term diabetes complications: Such as kidney damage, vision loss, nerve issues, and cardiovascular disease.

Benefits

• Superior glycemic control compared to metformin alone.

• May help reduce body weight and blood pressure.

• Supports heart and renal health in high-risk diabetic patients.

• Lower risk of hypoglycemia compared to some anti-diabetics.

Dosage & Administration

• Usual dose: 1 tablet once daily with food, preferably at the same time each day.

• Take whole with water; do not chew or break.

• Dose adjustments may be necessary based on kidney function, blood sugar response, and other health parameters—follow your doctor’s instructions strictly.

Common Side Effects

• Sore throat, nasal congestion, runny nose

• Nausea, vomiting, diarrhea

• Genital fungal infections, urinary tract infections

• Polyuria (frequent urination), dehydration

• Taste change, flatulence, skin rash

• Hypoglycemia (especially with missed meals, heavy exercise, or other anti-diabetic medicines)

• Dizziness, back pain

Most side effects improve as the body adapts. Notify your doctor if they persist or worsen.

Safety Advice

• Not recommended for people with type 1 diabetes or diabetic ketoacidosis.

• Caution in those with kidney or liver disorders.

• Avoid excessive alcohol intake, which may worsen risk of hypoglycemia or lactic acidosis.

• Pregnant or breastfeeding women should consult their doctor before using this medicine.

Laboratory Monitoring

• Fasting and postprandial blood glucose levels

• HbA1c (glycated hemoglobin)

• Renal function parameters

Composition Table

All details are verified from the manufacturer and trusted medicine databases for accuracy.

Note: Use CIPDAPLA-M 10/1000 Tablet strictly under physician supervision as part of a complete diabetes management plan, including diet, exercise, and regular monitoring.

CIPDAPLA-M 10/500 Tablet is a prescription combination medicine formulated for the management of Type 2 Diabetes Mellitus. It provides dual glycemic control with two complementary anti-diabetic agents:

• Dapagliflozin (10mg): A sodium-glucose co-transporter 2 (SGLT2) inhibitor that promotes the removal of excess blood glucose via urine, working independently of insulin.

• Metformin Hydrochloride (500mg): A biguanide that reduces hepatic glucose production, delays glucose absorption from the intestines, and enhances insulin sensitivity.

Mechanism of Action

• Dapagliflozin: Inhibits SGLT2 in the kidneys, blocking glucose reabsorption, thereby increasing urinary glucose excretion and lowering blood sugar levels.

• Metformin: Lowers glucose production in the liver, improves insulin response, and reduces intestinal glucose absorption; together, superior glycemic control is achieved compared to using either component alone.

Indications

• Type 2 Diabetes Mellitus: Used for adults when diet, exercise, and other single-agent (monotherapy) treatments do not achieve adequate glycemic control.

• Prevention of complications: Helps lower risk of diabetic complications including kidney, nerve, eye, and heart disorders.

Benefits

• Reduced fasting and postprandial blood sugar levels

• Supports weight management and lowering of blood pressure

• Decreases risk of cardiovascular complications in high-risk diabetic patients

• Low risk of hypoglycemia when used alone (but risk increases if taken with other anti-diabetic medication or missed meals).

Dosage & Administration

• Typical dose: 1 tablet once daily with food, at the same time every day.

• Take whole with water; do not chew or break.

• Strictly follow doctor’s instructions for dosage and duration, as dose adjustment may be needed in patients with kidney or liver impairment.

Common Side Effects

• Genital fungal infections, urinary tract infections

• Increased urination (polyuria)

• Nausea, vomiting, diarrhea

• Flatulence, skin rash, taste changes

• Runny nose, sore throat (nasopharyngitis)

• Dizziness, weakness, back pain

• Dehydration (drink plenty of fluids to prevent)

Most side effects decrease as your body adjusts. Seek medical advice for persistent or severe symptoms.

Important Safety Information

• Not recommended for type 1 diabetes or diabetic ketoacidosis.

• Avoid in pregnancy and breastfeeding (limited safety data; consult your doctor).

• Avoid alcohol, which may increase risk of lactic acidosis, dehydration, or hypoglycemia.

• Use with caution in kidney or liver disorders—doctor may modify dose or recommend additional monitoring.

• Regularly monitor blood sugar and kidney function while on treatment.

Composition Table

Note: Use CIPDAPLA-M 10/500 strictly as prescribed, alongside a healthy diet, exercise, and regular monitoring to optimize diabetes management.

CIPVILDIN-M 50/500 Tablet is a combination oral medication produced by Cipla Ltd for the management of Type 2 Diabetes Mellitus. Each tablet contains Vildagliptin 50mg, a DPP-4 inhibitor, and Metformin Hydrochloride IP 500mg, a well-established biguanide anti-diabetic agent.

Vildagliptin helps regulate blood sugar by increasing the levels and activity of incretin hormones, which stimulate glucose-dependent insulin release from the pancreas and suppress the hormone glucagon, thereby preventing excessive glucose production in the liver. Metformin complements these effects by reducing hepatic glucose production, enhancing insulin sensitivity in muscle tissues, and decreasing glucose absorption from the gut. Together, these actions lead to better control of both fasting and postprandial (after meal) blood sugar.

This combination is usually prescribed for adults with Type 2 diabetes when diet, exercise, or monotherapy do not adequately control blood sugar levels. The lower metformin dose (500mg) may be preferred for individuals new to metformin or those sensitive to gastrointestinal side effects.

Typical side effects may include nausea, diarrhea, abdominal discomfort (from metformin), headache, dizziness, mild hypoglycemia (especially with other diabetes medicines or missed meals), and upper respiratory symptoms. Severe kidney impairment, liver dysfunction, and Type 1 diabetes or diabetic ketoacidosis are contraindications for use. Regular kidney and liver
function monitoring, as well as routine blood sugar checks, are recommended during therapy.

CIPVILDIN-M 50/500 Tablets should be taken exactly as directed by your physician, preferably with meals to minimize stomach upset. Adherence to diet, exercise, and regular check-ups is essential for optimal diabetes management with this therapy. Always consult your healthcare provider before making any changes to your diabetes regimen.

COBAFAST FORTE Capsule is a combination supplement supporting nerve health, glucose metabolism, and antioxidant protection, most commonly used in the management of diabetic neuropathy and other vitamin deficiency–related nerve disorders.

Uses / Indications

• Diabetic neuropathy & nerve pain: Reduces tingling, numbness, burning, and pain in hands/feet; supports nerve protection and repair.

• Alcoholic or drug-induced neuropathy: Used as co-prescription for nerve recovery in patients with neurological symptoms from alcohol or certain medications.

• General nutritional deficiency: Improves health where vitamin B deficiencies or oxidative stress impair nerve and metabolic health.

• Postherpetic neuropathy & other nerve disorders: Useful as an adjunct in various neuropathic and chronic vitamin deficiency conditions.

• Glucose and energy metabolism: Benfotiamine and inositol aid in blood sugar regulation and energy production.

Ingredient Benefits

• Benfotiamine: Fat-soluble vitamin B1 derivative—improves nerve function, glucose metabolism, and helps reduce advanced glycation end-products.

• Mecobalamin (B12): Repairs and regenerates nerves, supports healthy red blood cells and brain/nerve function.

• Alpha Lipoic Acid: Antioxidant—protects nerves against oxidative stress and cellular aging.

• Inositol: Supports nerve cell signaling and metabolic health; beneficial in nerve and mood regulation.

• Pyridoxine (B6): Vital for nerve metabolism, reduces risk of vitamin B6 deficiency–related neuropathy.

• Folic Acid: Helps with DNA synthesis, nerve healing, and red blood cell formation.

Dosage & Administration

• Take one capsule daily (or as advised) with a glass of water, after food for better tolerance.

• Regular use provides optimal results—never exceed prescribed dose.

• Maintain a balanced diet rich in B-vitamins and antioxidants for synergistic benefits.

Safety & Side Effects

• Common: Mild nausea, headache, dizziness, diarrhea, stomach upset, loss of appetite—usually temporary.

• Avoid in known allergies to any ingredients. Tell your doctor if taking other vitamin supplements or medicines.

• Safe for long-term use as directed—use in pregnancy/breastfeeding should be under medical advice.

• Rare: Excessive vitamin B6 can cause neuropathy if taken at high levels for extended periods—stick to dosage guidance.

Note:
COBAFAST FORTE is a prescription supplement for nerve and metabolic health—especially for people with diabetes, chronic alcoholism, or long-standing nutritional deficiencies. It is meant to complement (not replace) standard diabetes or neuropathy care.

DAILYGLIM M1 FORTE Tablet is a fixed-dose combination oral antidiabetic for adults with type 2 diabetes who need stronger dual therapy for optimal blood sugar control.

Uses / Indications

• Type 2 diabetes mellitus: For persistent hyperglycemia in adults when diet, exercise, or lower-strength medicines are insufficient.

• Prevents diabetes complications: Regular use helps protect against kidney, eye, nerve, heart, and vascular damage caused by poorly controlled diabetes.

How it Works / Key Benefits

• Glimepiride: Stimulates pancreatic insulin release, improves glucose uptake, and lowers postprandial blood sugar.

• Metformin (PR): Reduces liver glucose production, delays intestinal glucose absorption, increases peripheral insulin sensitivity; prolonged release ensures steady effect with reduced GI side effects.

• The bilayered tablet provides synergistic glucose control, lowering HbA1c more effectively than either agent alone.

Dosage & Administration

• Usually one tablet daily with the first major meal (preferably breakfast); exact dose, duration, and timing are determined by the physician.

• Swallow whole with water; do not chew, crush, or break.

• Take at the same time daily, maintain regular meals, and monitor blood sugar routinely.

• Do not double dose if missed; continue scheduled dosing.

Safety & Side Effects

• Common: Low blood sugar (hypoglycemia), mild GI upset (nausea, diarrhea), taste disturbance, weight changes, headache.

• Serious/rare: Lactic acidosis with metformin (seek urgent care for rapid breathing, vomiting), allergic reactions, anemia, liver/kidney dysfunction.

• Not for type 1 diabetes, diabetic ketoacidosis, severe kidney/liver impairment, or in metabolic acidosis.

• Alcohol and some medicines increase risk of adverse effects—avoid without medical advice.

• Regular monitoring of blood, kidney, and liver function is recommended during use.

Note:
DAILYGLIM M1 FORTE is for long-term diabetes control. Continue a healthy lifestyle and physician follow-up for best results and safety.

DAILYGLIM M2 Tablet is a fixed-dose combination oral antidiabetic for adults with type 2 diabetes, used when diet, exercise, or single-agent therapy don’t offer adequate blood glucose control.

Uses / Indications

• Type 2 diabetes mellitus: For persistent high blood sugar in adults; may be prescribed alone or with other diabetes therapies.

• Aims to reduce long-term complications (kidney, nerve, eye, and heart disease) from uncontrolled diabetes.

How it Works / Key Benefits

• Glimepiride: Stimulates pancreatic insulin release and improves the body’s insulin response, lowering blood sugar after meals.

• Metformin (PR): Reduces liver glucose production, limits intestinal glucose absorption, and increases insulin sensitivity.

• Dual-action control: More effective at lowering blood sugar than either drug alone, with a lower risk of hypoglycemia compared to traditional sulfonylureas.

Dosage & Administration

• Usually one bilayered tablet daily, taken with food, preferably with breakfast.

• Swallow whole with water—do not split, crush, or chew.

• Always take at the same time each day and never skip meals; continue blood sugar monitoring.

• Never double the dose if missed; resume at the normal schedule.

Safety & Side Effects

• Common: Hypoglycemia (sweating, shakiness, confusion), nausea, stomach upset, diarrhea, headache, modest weight gain, taste changes.

• Rare/Serious: Allergic reaction, lactic acidosis (rapid breathing, vomiting), anemia, liver/kidney dysfunction.

• Not for type 1 diabetes, ketoacidosis, severe kidney/liver dysfunction, or metabolic acidosis.

• Avoid alcohol—raises hypoglycemia risk.

• Regular checks of sugar, kidney, and liver function are recommended.

Note:
DAILYGLIM M2 is part of a complete diabetes care plan—continue healthy diet, exercise, and follow medical directions for best results and safety.